abstract：:Since chromium(III) was demonstrated to have antioxidative action, we have decided to study the effect of this element on V-induced LPO in liver and kidney of rats. Outbred 2-month-old, albino male Wistar rats received daily, for a period of 12 weeks: group I (control), deionized water to drink; group II, sodium metav...

journal_title：Chemico-biological interactions

authors： Scibior A,Zaporowska H,Ostrowski J,Banach A

更新日期：2006-02-25 00:00:00

abstract：:The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. In our previous study, we reported the antioxidant and anticarcinogenic effect of W. somnifera (L.) Dunal along with pa...

journal_title：Chemico-biological interactions

authors： Senthilnathan P,Padmavathi R,Banu SM,Sakthisekaran D

更新日期：2006-02-25 00:00:00

abstract：:We have previously shown that subclinical hypervitaminosis A in rats causes fragile bones. To begin to investigate possible mechanisms for Vitamin A action we extended our previous study. Forty-five mature female Sprague-Dawley rats were divided into three groups, each with 15 animals. They were fed a standard diet co...

journal_title：Chemico-biological interactions

authors： Lind PM,Johansson S,Rönn M,Melhus H

更新日期：2006-01-05 00:00:00

abstract：:Over the last few years, several laboratories have focused their attention on elucidating the molecular events that control the expression and localization of acetylcholinesterase (AChE) in neurons and skeletal muscle cells. In this context, results from a number of studies have clearly shown the important contributio...

journal_title：Chemico-biological interactions

authors： Deschênes-Furry J,Angus LM,Bélanger G,Mwanjewe J,Jasmin BJ

更新日期：2005-12-15 00:00:00

abstract：:It is now widely accepted that acetylcholinesterase (AChE) also displays non-cholinergic functions, completely independent of cholinergic transmission. Indeed, AChE has been implicated in a variety of trophic and toxic actions in a range of different systems. However, it is still uncertain what part of the AChE molecu...

journal_title：Chemico-biological interactions

authors： Greenfield S

更新日期：2005-12-15 00:00:00

abstract：:The asymmetric A12 acetylcholinesterase (AChE) molecular form, consisting of three tetrameric catalytic oligomers and three non-catalytic subunits of collagen Q (ColQ), is the functional AChE form in the neuromuscular junction. Its extremely high concentration and sharp localization in the junction is mostly due to th...

journal_title：Chemico-biological interactions

authors： Crne-Finderle N,Pregelj P,Sketelj J

更新日期：2005-12-15 00:00:00

abstract：:Nicotiana benthamiana plants were engineered to express a codon-optimized gene encoding the human acetylcholinesterase-R (AChE) isoform. The transgenic plants expressed the protein at >0.4% of total soluble protein, and the plant-produced enzyme was purified to homogeneity. Following lysis, procainamide affinity chrom...

journal_title：Chemico-biological interactions

authors： Geyer BC,Muralidharan M,Cherni I,Doran J,Fletcher SP,Evron T,Soreq H,Mor TS

更新日期：2005-12-15 00:00:00

abstract：:The anticancer prodrug CPT-11 is a highly effective camptothecin analog that has been approved for the treatment of colon cancer. The 2.6 angstroms resolution crystal structure of its complex with Torpedo californica acetylcholinesterase (TcAChE) demonstrates that CPT-11 binds to TcAChE and spans its gorge similarly t...

journal_title：Chemico-biological interactions

authors： Harel M,Hyatt JL,Brumshtein B,Morton CL,Wadkins RM,Silman I,Sussman JL,Potter PM

更新日期：2005-12-15 00:00:00

abstract：:Cholinesterases (ChEs) are classified as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) according to their substrate specificity and sensitivity to selected inhibitors. The activities of AChE in red blood cells (RBC-AChE) and BChE in serum can be used as potential biomarkers of suppressed and/or heighten...

journal_title：Chemico-biological interactions

authors： Gordon RK,Haigh JR,Garcia GE,Feaster SR,Riel MA,Lenz DE,Aisen PS,Doctor BP

更新日期：2005-12-15 00:00:00

abstract：:p-Aminobenzoic acid (p-ABA) derivatives were evaluated as acetylcholinesterase inhibitors (AChEIs). Finding a correlation between AChE activity with the partition coefficient (log P) and the highest occupied molecular orbital (HOMO) energy of the compounds. ...

journal_title：Chemico-biological interactions

authors： Correa-Basurto J,Espinosa-Raya J,Vázquez-Alcántara I,Flores-Sandoval CA,Trujillo-Ferrara J

更新日期：2005-12-15 00:00:00

abstract：:Butyrylcholinesterase (BChE) constitutes the first line defense in the serum of higher organisms and is a marker for toxic exposure. Indole-3-acetic acid (IAA) is a major plant growth hormone of the auxin class, affecting cell enlargement, and differentiation. As a result of the industrial usage, this agrochemical is ...

journal_title：Chemico-biological interactions

authors： Bodur E,Cokugras AN

更新日期：2005-12-15 00:00:00

abstract：:We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities. Merosin deficiency causes an important decrease (46%) in AChE specific activity. Thymus produces dimers, monomers and tetramers of AChE,...

journal_title：Chemico-biological interactions

authors： Sánchez del Campo L,Nieto-Cerón S,Muñoz-Delgado E,Vidal CJ,Campoy FJ

更新日期：2005-12-15 00:00:00

abstract：:Although the involvement of cholinesterases (ChEs) in the removal of acetylcholine (ACh) at cholinergic synapses is firmly established, there is evidence to suggest that acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) take part in several cellular processes. The early expression of ChE genes during embry...

journal_title：Chemico-biological interactions

authors： Vidal CJ

更新日期：2005-12-15 00:00:00

abstract：:We have investigated the role of Vitamin A (retinoid) proteins in hepatic retinoid processing under normal conditions and during chemical stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a chemical known to interfere with retinoid turnover and metabolism. Three separate studies were performed in wildtype ...

journal_title：Chemico-biological interactions

authors： Hoegberg P,Schmidt CK,Fletcher N,Nilsson CB,Trossvik C,Gerlienke Schuur A,Brouwer A,Nau H,Ghyselinck NB,Chambon P,Håkansson H

更新日期：2005-09-10 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-diphosphoglycerate, one of the precursors for glycolytic ATP biosynthesis. The enzyme contains an active site cysteine thiolate, which is critical for its catalytic function. As part of a conti...

journal_title：Chemico-biological interactions

authors： Rodriguez CE,Fukuto JM,Taguchi K,Froines J,Cho AK

更新日期：2005-06-30 00:00:00

abstract：:This article presents an overview of occupational benzene exposures in China based on data published in Chinese medical journals. The data were derived from 384 reports of benzene poisoning or industrial hygiene surveys published in Chinese medical journals between 1960 and 2003. The following information was extracte...

journal_title：Chemico-biological interactions

authors： Liang YX,Wong O,Armstrong T,Ye XB,Miao LZ,Zhou YM,Wu QE,Qian HJ,Fu H

更新日期：2005-05-30 00:00:00

abstract：:NADPH:quinone oxidoreductase 1 (NQO1) may perform multiple functions within the cell. It is known to detoxify benzene-derived quinones and generate antioxidant forms of ubiquinone and Vitamin E. Recently suggested roles for NQO1 which may have relevance for mechanisms underlying benzene toxicity include modulation of ...

journal_title：Chemico-biological interactions

authors： Ross D

更新日期：2005-05-30 00:00:00

abstract：:Benzene (B) is a typical micro-pollutant present in air, especially urban air. In this study a possible correlation between personal benzene exposure and S-phenylmercapturic acid (S-PMA) as a biomarker of internal dose was evaluated in a cohort of traffic policemen. The results confirm that S-PMA is significantly corr...

journal_title：Chemico-biological interactions

authors： Bono R,Traversi D,Maestri L,Schilirò T,Ghittori S,Baiocchi C,Gilli G

更新日期：2005-05-30 00:00:00

abstract：:This study was undertaken to evaluate the effects of age on a child's susceptibility to developing leukemia following exposure to known leukemogenic agents. The clinical literature describing the risk of developing acute myelogenous leukemia (AML) following treatment with alkylating agents or topoisomerase reactive dr...

journal_title：Chemico-biological interactions

authors： Pyatt DW,Hays SM,Cushing CA

更新日期：2005-05-30 00:00:00

abstract：:The characterization of the metabolic pathways of new chemical entities with a special emphasis on detecting potentially reactive metabolites is increasingly being performed early in the drug discovery process. In the present study, the preliminary in vitro metabolic routes of a series of novel 2-substituted benzothio...

journal_title：Chemico-biological interactions

authors： Evans CA,Fries HE,Ward KW

更新日期：2005-02-28 00:00:00

abstract：:In a previous preliminary investigation, we reported on the excretion, tissue disposition and metabolism of the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate (p-XSC) in the rat, but similar studies in the mouse have not been explored. Following the oral administration of p-XSC (50 micromol/kg body wei...

journal_title：Chemico-biological interactions

authors： Sohn OS,Desai DH,Das A,Rodriguez JG,Amin SG,El-Bayoumy K

更新日期：2005-02-10 00:00:00

abstract：:The ability of lysolipids to enter into a membrane bi-layer and disturb the membrane structure was used to study the behavior of K562 erythroleukemic cells, K562 wild type (K562wt) as well as the multidrug resistant cells K562adr. Both types of cells, when analyzed by proton NMR spectroscopy exhibit the high resolutio...

journal_title：Chemico-biological interactions

authors： Traïkia M,Marbeuf-Gueye C,Hantz E,Le Moyec L

更新日期：2005-01-15 00:00:00

abstract：:Fumonisin B1 induces cytotoxicity in sensitive cells by inhibiting ceramide synthase due to its structural similarity to the long-chain backbones of sphingolipids. The resulting accumulation of sphingoid bases has been established as a mechanism for fumonisin B1 cytotoxicity. We found that despite the accumulation of ...

journal_title：Chemico-biological interactions

authors： Sharma N,He Q,Sharma RP

更新日期：2004-12-30 00:00:00

abstract：:Cigarette smoke is a major risk factor for human diseases, such as lung cancer and atherosclerosis. The present study was undertaken to investigate the effect of non-fractionated water-soluble cigarette smoke extract (NFWS CSE) on DNA damage and cellular adhesion molecule expression in human umbilical vein endothelial...

journal_title：Chemico-biological interactions

authors： Chen HW,Chien ML,Chaung YH,Lii CK,Wang TS

更新日期：2004-12-07 00:00:00

abstract：:This study was planned to determine the protective role of zinc, if any, in attenuating the toxicity induced by nickel sulfate in rat liver. Female Sprague Dawley (SD) rats received either nickel alone in the dose of 800 mg/l in drinking water, zinc alone in the dose of 227 mg/l in drinking water, and nickel plus zinc...

journal_title：Chemico-biological interactions

authors： Sidhu P,Garg ML,Dhawan DK

更新日期：2004-11-20 00:00:00

abstract：:Susceptibility to drug toxicity is influenced by a variety of factors, both genetic and environmental. The focus of this article is the evidence addressing the hypothesis that inflammation is both a result of and a susceptibility factor for drug toxicity, with an emphasis on liver as a target organ. Results of studies...

journal_title：Chemico-biological interactions

authors： Ganey PE,Luyendyk JP,Maddox JF,Roth RA

更新日期：2004-11-01 00:00:00

abstract：:In cancer, a high flux of oxidants not only depletes the cellular thiols, but damages the whole cell as well. Epidemiological studies suggest green tea may mitigate cancers in human and animal models for which several mechanisms have been proposed. In the present investigation, the levels of cellular thiols such as re...

journal_title：Chemico-biological interactions

authors： Srinivasan P,Sabitha KE,Shyamaladevi CS

更新日期：2004-10-15 00:00:00

abstract：:Oxalate induced renal calculi formation and the associated renal injury is thought to be caused by free radical mediated mechanisms. An in vivo model was used to investigate the effect of phycocyanin (from Spirulina platensis), a known antioxidant, against calcium oxalate urolithiasis. Male Wistar rats were divided in...

journal_title：Chemico-biological interactions

authors： Farooq SM,Asokan D,Kalaiselvi P,Sakthivel R,Varalakshmi P

更新日期：2004-08-10 00:00:00

abstract：:Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects the kidney from the aminoglycosides-induced nephrotoxicity. Gentamicin, a typical aminoglycoside, is reported to cause lipid peroxidation. We focused on lipid ...

journal_title：Chemico-biological interactions

authors： Yanagida C,Ito K,Komiya I,Horie T

更新日期：2004-07-20 00:00:00

abstract：:Normal reproductive development depends on the interplay of steroid hormones with their receptors at specific tissue sites. The concentrations of hormone ligands in the circulation and at target sites are maintained through coordinated regulation on steroid biosynthesis and degradation. Changed bioavailability of ster...

journal_title：Chemico-biological interactions

authors： You L

更新日期：2004-04-15 00:00:00

abstract：:It is known that procymidone modifies sexual differentiation in vivo and in vitro, and that it induces vitellogenin (Vtg) synthesis in primary cultured rainbow trout hepatocytes. The aim of this study was to evaluate the mechanism underlying this latter in vitro estrogenic action. The cells were treated for 24 h with ...

journal_title：Chemico-biological interactions

authors： Radice S,Fumagalli R,Chiesara E,Ferraris M,Frigerio S,Marabini L

更新日期：2004-03-15 00:00:00

abstract：:A detailed subfractionation of the non-pregnant porcine corpus luteum (CL) was performed employing differential centrifugation. Marker enzyme assays (i.e., lactate dehydrogenase for the cytosol, NADPH-cytochrome P450 reductase for the endoplasmatic reticulum, catalase (CAT) for peroxisomes, glutamate dehydrogenase for...

journal_title：Chemico-biological interactions

authors： Boström M,Björk K,Nelson BD,DePierre JW

更新日期：2004-01-15 00:00:00

abstract：:This study investigated the spectral interactions of hepatic microsomal cytochrome p450 (CYP) enzymes with four symmetrical polychlorinated biphenyls (PCBs): 2,2',4,4'-tetrachlorobiphenyl (PCB 47); 2,2',5,5'-tetrachlorobiphenyl (PCB 52); 2,2',6,6'-tetrachlorobiphenyl (PCB 54); and 3,3',4,4'-tetrachlorobiphenyl (PCB 77...

journal_title：Chemico-biological interactions

authors： Hrycay EG,Bandiera SM

更新日期：2003-12-15 00:00:00

abstract：:We examined radiosensitizing properties of two novel platinum complexes (ethylenediamine(L-malato)platinum(II)), Pt1 and bis(1-ethylimidazole(L-malato)platinum(II)), Pt4. Initial double strand break (DSB) level and DSB rejoining were measured, using pulse field gel electrophoresis (PFGE) in human G1 phase lymphocytes ...

journal_title：Chemico-biological interactions

authors： Gradzka I,Buraczewska I,Kuduk-Jaworska J,Romaniewska A,Szumiel I

更新日期：2003-10-25 00:00:00

abstract：:Lanthanides (Ln) were known to induce cell apoptosis, which might be the results of their effects on mitochondria (MT). This study was trying to clarify the role of MT and reactive oxygen species (ROS) in Ln-induced apoptosis. We found that micromolar or lower concentration of La(3+), Gd(3+) and Yb(3+) bound to MT and...

journal_title：Chemico-biological interactions

authors： Liu H,Yuan L,Yang X,Wang K

更新日期：2003-07-25 00:00:00

abstract：:Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. Evening primrose extract (EPE) is extracted from Oenothera biennis L., one species of evening primroses, which has been shown to have several pharmacological effects. However, anti-tumor activity in the extract of defatted s...

journal_title：Chemico-biological interactions

authors： Arimura T,Kojima-Yuasa A,Watanabe S,Suzuki M,Kennedy DO,Matsui-Yuasa I

更新日期：2003-06-15 00:00:00

abstract：:In the present study, the inhibition of human glutathione S-transferase P1-1 (GSTP1-1) by the flavonoid quercetin has been investigated. The results show a time- and concentration-dependent inhibition of GSTP1-1 by quercetin. GSTP1-1 activity is completely inhibited upon 1 h incubation with 100 microM quercetin or 2 h...

journal_title：Chemico-biological interactions

authors： van Zanden JJ,Ben Hamman O,van Iersel ML,Boeren S,Cnubben NH,Lo Bello M,Vervoort J,van Bladeren PJ,Rietjens IM

更新日期：2003-05-06 00:00:00

abstract：:Vitamin A (retinoids) has an essential role in development and throughout life of humans and animals. Consequently, effects of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on retinoid metabolism may be contributory to its toxicity. This study was performed to clarify the mechanism behind diox...

journal_title：Chemico-biological interactions

authors： Hoegberg P,Schmidt CK,Nau H,Ross AC,Zolfaghari R,Fletcher N,Trossvik C,Nilsson CB,Håkansson H

更新日期：2003-03-06 00:00:00

abstract：:Transient up-regulation of ALDH3A1, CYP1A1 and CYP1B1 transcription by transient exposure to aryl hydrocarbon receptor (AhR) ligands, e.g. 3-methylcholanthrene, is via transient transactivation of xenobiotic responsive elements (XRE) present in the 5'-upstream regions of these genes. Others have shown that AhR ligand-...

journal_title：Chemico-biological interactions

authors： Sládek NE

更新日期：2003-02-01 00:00:00

abstract：:Two aldehyde dehydrogenases (ALDH) were purified from the liver of black seabream (Acanthopagrus schlegeli). Chromatography of the liver homogenate on an alpha-cyanocinnamate-Sepharose affinity column results in two activity peaks using acetaldehyde as the substrate. The eluate was subjected to another affinity chroma...

journal_title：Chemico-biological interactions

authors： Fong WP,Cheng CH,Tang WK

更新日期：2003-02-01 00:00:00